Hey2 functions in parallel with Hes1 and Hes5 for mammalian auditory sensory organ development
نویسندگان
چکیده
منابع مشابه
Hes1 and Hes5 as notch effectors in mammalian neuronal differentiation.
While the transmembrane protein Notch plays an important role in various aspects of development, and diseases including tumors and neurological disorders, the intracellular pathway of mammalian Notch remains very elusive. To understand the intracellular pathway of mammalian Notch, the role of the bHLH genes Hes1 and Hes5 (mammalian hairy and Enhancer-of-split homologues) was examined by retrovi...
متن کاملHes1 and Hes5 activities are required for the normal development of the hair cells in the mammalian inner ear.
The mammalian inner ear contains two sensory organs, the cochlea and vestibule. Their sensory neuroepithelia are characterized by a mosaic of hair cells and supporting cells. Cochlear hair cells differentiate in four rows: a single row of inner hair cells (IHCs) and three rows of outer hair cells (OHCs). Recent studies have shown that Math1, a mammalian homolog of Drosophila atonal is a positiv...
متن کاملWe have characterised the functions of the bHLH transcriptional repressors HES1 and HES5 in neurogenesis, using the development of the olfactory placodes in mouse embryos as a model. Hes1 and Hes5 are expressed with distinct patterns in the olfactory placodes
The generation of the numerous types of neurons that constitute the adult nervous system from an initially homogenous population of neurectodermal progenitor cells is an extremely complex process, which has been thoroughly investigated, first in Drosophila (Campos-Ortega, 1993; Jan and Jan, 1994) and, more recently, in vertebrates (Tanabe and Jessell, 1996; Chan and Jan, 1999). In vertebrates, ...
متن کاملHes1 and Hes5 regulate vascular remodeling and arterial specification of endothelial cells in brain vascular development
The vascular system is the first organ to form in the developing mammalian embryo. The Notch signaling pathway is an evolutionarily conserved signaling mechanism essential for proper embryonic development in almost all vertebrate organs. The analysis of targeted mouse mutants has demonstrated essential roles of the Notch signaling pathway in embryonic vascular development. However, Notch signal...
متن کاملdevelopment and implementation of an optimized control strategy for induction machine in an electric vehicle
in the area of automotive engineering there is a tendency to more electrification of power train. in this work control of an induction machine for the application of electric vehicle is investigated. through the changing operating point of the machine, adapting the rotor magnetization current seems to be useful to increase the machines efficiency. in the literature there are many approaches wh...
15 صفحه اولذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: BMC Developmental Biology
سال: 2008
ISSN: 1471-213X
DOI: 10.1186/1471-213x-8-20